Hyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. The aim of this study is to investigate homocysteine, folic acid and vitamin B12 levels in a cohort of psoriatic patients and its relationship with the severity of the disease. A retrospective observational study in 98 patients with chronic plaque psoriasis and 98 healthy controls was performed. Total plasma homocysteine level, folic acid, vitamin B₁₂ and PASI index were assessed in every patient. Patients with psoriasis had plasma homocysteine levels higher than controls (57% of cases and 25% of controls; p12 plasma levels were lower in psoriatic patients than in controls (p = NS), lower levels of vitamin B₁₂ were found in patients with hyperhomocysteinaemia compared to patients with a normal value of homocysteine (p = 0.0009). The severity of psoriasis assessed according to PASI (±) did not directly correlate either with higher levels of homocysteine or with vitamin B₁₂ and folic acid plasma levels. In conclusion, a significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls. A significant correlation between hyperhomocysteinaemia and lower vitamin B₁₂ levels, but not folic acid, was evidenced. On the contrary, our data do not correlate the high level of homocysteine with higher PASI scores or psoriasis type, suggesting that homocysteine level can be considered an independent risk factor in psoriatic patients.

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N2 – Hyperhomocysteinaemia means another chance basis to possess atherosclerotic heart disease, coronary arrest, peripheral arterial occlusive situation and you may venous thrombosis. Psoriasis is actually a persistent inflammatory skin condition on the improved atherothrombosis and you will cardiovascular risk character. The purpose of this research would be to investigate homocysteine, folic acid and vitamin B12 levels from inside the good cohort off psoriatic clients as well as reference to the seriousness of the condition. A great retrospective observational research within the 98 clients which have persistent plaque psoriasis and 98 compliment controls is performed. Total plasma homocysteine level, folic acidic, nutritional B12 and you will PASI list had been examined in every patient. Patients with psoriasis got plasma homocysteine levels more than control (57% from circumstances and twenty-five% out of controls; p12 plasma account had been low in psoriatic patients compared to control (p = NS), low levels off vitamin B12 have been found in customers that have hyperhomocysteinaemia as compared to customers having a normal value of homocysteine (p = 0.0009). The severity of psoriasis analyzed according to PASI (±) did not in person correlate both with highest levels of homocysteine otherwise that have vitamin B12 and you can folic acid plasma accounts. To close out, a somewhat higher frequency out-of hyperhomocysteinaemia are included in psoriatic customers than the suit control. A critical relationship between hyperhomocysteinaemia and lower vitamin B12 profile, however folic acid, is confirmed. Quite the opposite, our very own data don’t associate the fresh new higher level out-of homocysteine that have higher PASI score or psoriasis particular, suggesting that homocysteine peak is regarded as a separate chance basis for the psoriatic patients.

Abdominal – Hyperhomocysteinaemia is short for an independent exposure basis getting atherosclerotic cardiovascular disease, coronary attack, peripheral arterial occlusive situation and you will venous thrombosis. Psoriasis are a long-term inflammatory skin disease for the increased atherothrombosis and aerobic risk character. The purpose of this study would be to have a look at homocysteine, folic acid and supplement B12 profile from inside the good cohort of psoriatic people and its right here own connection with the seriousness of the disease. Good retrospective observational analysis when you look at the 98 people which have persistent plaque psoriasis and you may 98 compliment control is actually did. Total plasma homocysteine top, folic acid, nutritional B12 and you will PASI index was basically reviewed in any diligent. Clients which have psoriasis had plasma homocysteine membership more than regulation (57% regarding circumstances and you can twenty-five% off regulation; p12 plasma levels was indeed low in psoriatic customers than in control (p = NS), lower levels of vitamin B12 have been used in clients which have hyperhomocysteinaemia versus customers having a normal value of homocysteine (p = 0.0009). The severity of psoriasis examined centered on PASI (±) failed to yourself correlate sometimes which have high quantities of homocysteine otherwise that have nutritional B12 and you will folic acid plasma membership. To close out, a significantly large prevalence out of hyperhomocysteinaemia try used in psoriatic people compared to fit control. A critical correlation between hyperhomocysteinaemia minimizing vitamin B12 membership, but not folic acid, is confirmed. On the contrary, our very own data don’t associate the new advanced level regarding homocysteine that have large PASI ratings otherwise psoriasis sorts of, indicating that homocysteine height is regarded as an independent exposure foundation within the psoriatic people.